Sulfobutyl Ether Bate Cyclodextrin
Quick Details
|
Name |
Sulfobutyl Ether B cyclodextrin |
|
CAS No. |
182410-00-0 |
|
DMF No. |
030167 |
|
Abbreviation |
SBEBCD |
|
Appearance |
White powder, sweet, insipid and innocuous |
|
Assay |
95.0%-105.0% |
|
Availability |
In stock |
Molecular structuer:
Product Introduction
Sulfobutyl Ether Beta-Cyclodextrin Injection is a highly water-soluble anionic cyclodextrin derivative (CAS#: 182410-00-0). Sulfobutyl Ether Beta-Cyclodextrin can readily form non-covalent inclusion complexes with drug molecules, offering significant advantages such as:
1,Enhancing drug stability, solubility, and safety
2,Reducing drug toxicity and hemolysis
3,Masking unpleasant odors
4,Controlling drug release rates
Product Specification
|
Appearance |
White or almost white,hygroscopic powder |
|
Solubility |
Fneely soluble in water,practically insoluble in anhydrous ethanol and in methylene chloride. |
|
identification |
Same absorption bands as sulfobutylbetadexsodium CRS. |
|
Sodium |
It gives readtion of sodium. |
|
Assay |
98.0%-102.0% |
|
Beta Cyclodextrin |
≤1.0% |
|
1,4-Butane Sultono |
≤0.5ppm |
|
Chlorides |
≤0.12% |
|
4-Hydroxybutane-1-sulfonic Acid |
≤0.1% |
|
4,4-oxydi(butang-1-sulfonic acid) |
≤0.05% |
|
Bacterial Endotoxins |
≤20EU/g |
|
The total aerobic microblal count |
≤100cfu/g |
|
The total combined moulds and yeasts count |
≤100cfu/g |
|
Escherichia coli |
Absence |
|
Salmonella |
Absence |
|
Appearance of Solution |
Solution is clear and colourless |
|
Reducing sugars |
≤0.05% |
|
Average Degree of Substitution |
5.9-6.6 |
|
pH |
5.0-7.5 |
|
Water |
≤10.0% |
|
Packaging and storage |
In an airtight container |
Quality advantage
Features
Sulfobutyl Ether Beta-Cyclodextrin (SBECD) is a polyanionic sodium salt derived from beta-cyclodextrin, alkylated with 1,4-butanesultone under alkaline conditions. As a beta-cyclodextrin derivative with negatively charged side chains, it exhibits unique binding affinity for positively charged drugs.
The molecule adopts a truncated cone structure, with its hydrophobic cavity and alkyl ether side chains enabling efficient encapsulation of drug molecules to form non-covalent inclusion complexes. Key advantages include:
1,Enhanced drug solubility and stability
2,Improved drug safety profile
3,Reduced nephrotoxicity due to minimal renal reabsorption (accelerated excretion)
4,Excellent water solubility and low hemolytic potential
Application case
SBECD is widely used in various drug formulations, including:Injectable, oral, nasal, and ophthalmic preparations
Topical and inhalation formulations.It provides a protective microenvironment for active pharmaceutical ingredients (APIs), making it a versatile excipient with broad application prospects.
Packing&Storage
● Storage: Preserve well-closed containers protect from moisture.
● Packing: 100g/bag, 1kg/bag, 2kg/bag, 10kg/bag/drum, 20kg/bag/drum
Service advantages
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