Hydroxypropyl Beta Cyclodextrin CAS 128446-35-5

Molecular structuer:

Hydroxypropyl beta Cyclodextrin (HP-β-CD)is a hydroxyalkylated derivative of beta Cyclodextrin(β-CD). Hydroxypropyl β cyclodextrin is non-toxic and has no side effects.

Hydroxypropyl beta-cyclodextrin (HPβCD) finds applications in various fields, such as:

1.Pharmaceutical Field: HPβCD is commonly used in drug delivery systems to enhance the solubility, stability, and bioavailability of drugs. It forms inclusion complexes with drugs, leading to controlled drug release and prolonged drug efficacy. Additionally, it can improve the taste of drugs and mask their bitterness.

2.Food Industry: HPβCD serves as a food additive, providing enhanced flavor, texture, and stability. It is used to stabilize flavors, control the release of volatile compounds, and improve the taste and storage performance of food products.

3.Cosmetics Industry: HPβCD finds wide application in cosmetics to enhance the stability and penetration of active ingredients, improving the texture and efficacy of products. It is used in skincare products, makeup products, oral care products, and more.

4.Medical Device Field: HPβCD is also used in lubricants and protectants for medical devices. It improves the sliding performance of devices, reduces friction and wear, and enhances user experience and device lifespan.

1.Solubility: Hydroxypropyl cyclodextrin exhibits good water solubility, quickly dissolving in water to form a transparent or slightly yellowish solution.

2.Stability: Compared to regular cyclodextrin, hydroxypropyl cyclodextrin demonstrates higher stability under acidic and alkaline conditions, maintaining its properties and functionality.

3.Inclusion complex formation: With its molecular structure featuring a cyclic cavity, hydroxypropyl cyclodextrin can form inclusion complexes with various substances such as drugs, flavors, and cosmetic ingredients. This enhances their stability, water solubility, and bioavailability.

4.Mildness: Hydroxypropyl cyclodextrin exhibits good compatibility with most drugs and compounds, causing no significant adverse reactions or interactions.

5.Biocompatibility: Within a certain concentration range, hydroxypropyl cyclodextrin demonstrates good biocompatibility with humans and animals, causing no significant toxic side effects.

6.Solubility enhancement: Hydroxypropyl cyclodextrin can enhance the water solubility of hydrophobic drugs and compounds, thereby improving their dissolution rate and bioavailability.

When using hydroxypropyl beta-cyclodextrin (HPβCD), it's important to keep the following considerations in mind:

1.Use the appropriate concentration: Choose the appropriate concentration of HPβCD based on the specific application requirements. Different products and formulations may require different concentrations, so carefully read the product instructions or consult professionals for proper guidance.

2.Comply with regulations and safety requirements: Ensure compliance with applicable regulations and safety requirements when using HPβCD. This includes checking and adhering to regulatory requirements for pharmaceuticals, food, cosmetics, or other relevant products to ensure compliance and safety.

3.Be aware of allergic reactions: Some individuals may be allergic or sensitive to HPβCD. Conduct a skin sensitivity test before using HPβCD and closely observe for any allergic reactions. If any discomfort or allergic symptoms occur, discontinue use immediately and consult a doctor.

4.Storage and stability: When storing HPβCD, follow the manufacturer's recommendations. Typically, it is advised to store it in a dry, cool place, away from sunlight and heat sources. Ensure proper sealing of the container to maintain its stability and quality.

5.Compatibility: Consider the compatibility of HPβCD with other ingredients when formulating complex formulations. Some substances may affect the performance or stability of HPβCD, so thorough compatibility testing should be conducted during formulation design.

6.Understand product characteristics: It's essential to have a good understanding of the characteristics, properties, and scope of application of HPβCD. Detailed information on HPβCD's solubility, stability, complexation ability, and release properties can help optimize its use in specific products or formulations.

● Internal packing: packed PE bag, then put into aluminum foil bag

● Storage: Preserve well-closed containers protect from moisture.

● Label: accordingto customers' request.

● Outer packing: packed in drum.

● Packing:100g/bag, 1kg/bag, 2kg/bag, 10kg/bag/drum, 20kg/bag/drum

● Outer packaging: packed in carton or drum.

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