Betadex Sulfobutyl Ether Sodium
Betadex sulfobutyl ether sodium is a new anionic highly water-soluble Cyclodextrin derivative, which can be well combined with drug molecules to form a non covalent complex, thus improving the stability, water solubility and safety of drugs, reducing renal toxicity, easing drug hemolysis, controlling drug release rate, covering bad odor, etc. It has good solubilization, convenient drug delivery, safety, and stability. It can be used as a solvent, wetting agent, chelating agent (chelating agent), and multivalent masking agent.
Zhiyuan: Your Trustworthy Betadex Sulfobutyl Ether Sodium Manufacturer!
Shandong Binzhou Zhiyuan Biotechnology Co., Ltd is a leading direct supplier of cyclodextrin derivatives, cyclodextrin inclusion compounds and cyclodextrin reagents. Established in 2010, our company covers an area of 30,000 square meters, with a construction area of 10,000 square meters. We have our own GMP standard pharmaceutical excipient clean production workshop, a large pharmaceutical storage warehouse, and a quality inspection center. In addition, we have developed procedures for identifying the status of products at each stage and monitoring their raw materials, processes, quality testing, etc. to ensure that these products can be safely used in pharmaceuticals, food, cosmetics, spices, pesticides and other fields.
Rich Product Range
We have more than 70 kinds of cyclodextrins in 5 major series (natural cyclodextrins, cyclodextrin derivatives, cyclodextrin reagents, cyclodextrin complexes, and cyclodextrin polymers), and conduct research and development for different applications of new products.
Well Equipped
Our GMP workshop obtained the pharmaceutical production license in 2013 and passed ISO certification. It is currently equipped with ion chromatography (Ic), capillary electrophoresis (Ce), high-performance liquid chromatography, and Fourier transform infrared spectrometer (Ftir ) and other imported testing equipment.
Quality Assurance
All our products, including hydroxypropyl βdex, β-butanesulfonate sodium and hydroxypropyl γ-cyclodextrin, have been registered by DMF, approved by the US FDA, and have passed many standard certifications such as CP, USP, and EP.
Customizable Services
We have a complete R&D, quality inspection center and professional production team. We can customize the production of cyclodextrin products according to your needs, including their quantity, ingredients, packaging, and support OEM and ODM orders.
What Is Betadex Sulfobutyl Ether Sodium?
Betadex Sulfobutyl Ether Sodium (BSES) is a cyclodextrin that's used as a drug delivery solution. It's a chemically modified cyclodextrin with a structure that's designed to optimize the solubility and stability of drugs. It is prepared by alkylation of betadex using 1,4-butane sultone under basic conditions. It contains NLT 95.0% and NMT 105.0% of C42H70−nO35·(C4H8SO3Na)n (n = 6.2–6.9), calculated on the anhydrous basis.
Soluble
Betadex Sulfobutyl Ether Sodium is a sulfobutyl ether β-cyclodextrin derivative that can provide excellent excipients, quickly increase the solubility of poorly soluble drugs, and maintain solution stability after dissolution.
Wide Application
lubricants for aluminum pastes and silver pastes; react with formaldehyde, pyridine, and amines to be used as waterproofing agents, softeners, and antistatic agents; or used to prepare shampoos and shower gels ,cosmetic.
Simple to Use
They are highly soluble in water and insoluble in solvents such as acetone, methanol, and chloroform. They can easily form non-covalent inclusion complexes with drug molecules, control drug release rates, and mask the unpleasant odor and taste of drugs.
Multi Specifications
These cyclodextrins have a purity of up to 99% and are available as white to off-white solid powders, in different size packaging formats.
SBE-β-CD 7.5
SBE-β-CD 7.5 (Sulfobutylether-β-Cyclodextrin) is a chemically modified cyclodextrin that is used to increase the solubility and stability of drugs. It has a degree of substitution of 7.5 and is commonly used as a solubilizing agent for poorly-water soluble drugs. It is also used in drug delivery systems for targeted drug delivery. It is a polyanionic cyclic oligosaccharide that contains glucopyranose units forming a torus ring-like structure.
SBE-β-CD 12
SBE-β-CD 12 has a degree of substitution of 12 and is more hydrophilic than SBE-β-CD 7.5. It is often used in drug formulations where rapid drug release is required, such as in oral disintegrating tablets. It is used as an excipient or a formulating agent to increase the solubility of poorly soluble agents. It is also used to optimize the complexing and solubilizing agent for EN.
SBE-β-CD 16
It has a degree of substitution of 16 and is the most hydrophilic of all sulfobutyl ether sodium derivatives. It is often used as a solubilizing agent for highly hydrophobic drugs and as a stabilizer for protein formulations, to increase the solubility of poorly soluble agents. It is also used to optimize the solubility and stability of drugs.
Color
CD can adjust the color of food by increasing the solubility and chemical stability of coloring compounds (natural compounds and coloring components produced in food processing). They can inhibit the browning-promoting polyphenol oxidase reaction by compounding with several substrates or cofactors (such as chlorogenic acid, polyphenols, cinnamic acid and Cu 2+). A study shows that natural pigments curcumin and lycopene can form complexes with cyclodextrin, which improves their solubility and reduces the degree of oxidation compared with single compounds. Another study with chopped ginger roots showed that by adding 1-4% CD, the sample could be stably enzymatically browned at 5 C for 4 weeks under vacuum sealing.
Smell
Flavoring substances have a long history in food, although using them directly will bring a series of disadvantages, such as high volatility and sensitivity to light and heat. Some of these inconveniences can be solved by CD-based food flavor packaging, which is a common and simple solution to maintain stability. The price of β-CD encapsulated perfume ($ 5-6 per kilogram) will not be much higher than that of other microencapsulated spices. CD packaging can provide effective protection for each flavor component in a multi-component food system, regardless of the processing (freezing, thawing and/or microwave). The release of aroma in these compounds can be controlled by slow guest release, masking the odor of aroma components by affinity with CD cavity, and increasing food flavor by dissociating aroma water due to the polar external part of CD.
Taste
Bitterness is one of the factors leading to food rejection. However, there are exceptions to this rule, because some products are expected to have a certain degree of bitterness, such as coffee, beer or wine. By using appropriate CD, the bitter taste of some substances can be completely or partially eliminated, because the complex compound can not react with taste buds in the mouth. This taste will not be perceived, because only dissolved substances have a taste. The system has been applied to food (such as soybean), beverage (such as naringin in citrus juice or chlorogenic acid and polyphenols in coffee), cigarette smoke (nicotine) or bitter and astringent compounds in oral care products or drugs.
Improve Shelf Life
CD can protect many compounds in food from oxidation, light-induced reaction, thermal decomposition, self-decomposition, volatilization or sublimation loss and other reactions. Physical and chemical encapsulation of CD with lipophilic food ingredients can improve the stability of flavors, vitamins, dyes and unsaturated fats. Therefore, the shelf life of the product will be extended. For example, an in vitro study showed that CD encapsulation improved the stability of bioactive compounds of rosemary. Different accelerated and long-term storage stability tests show that the components compounded with CD have a longer life than those in the traditional formula. Another study tested 12 different β-CD complexes, which can be preserved for 14 years.
Antioxidation
CD can form a complex with components (spices, unsaturated fatty acids, dyes, etc.) sensitive to oxygen or oxidizing substances, which can improve the stability of packaging substrates in most cases. Many studies have shown that the chemical modification of these oxidizable substances can be almost completely prevented by complexing with such compounds, even when stored in the atmosphere of 100% oxygen. Another study showed that using cinnamon -CDs compound to make cinnamon-flavored dried apple slices could not only prevent the concentration of the compound from decreasing due to evaporation, but also prevent it from oxidation.
Prevent Photodegradation
CD can also be used to protect compounds of interest from deterioration factors such as light, heat or oxidation. In addition, if the CDs cavity is filled, the entry of other molecules will be prevented, so unnecessary reactions will not occur. Another mechanism is to prevent the reactive molecule from approaching the active site of the host molecule. For example, cyclodextrins have been used to protect vitamins and drugs containing oxidizable double bonds (such as prostaglandin). It has been proved that hydroxypropyl -β-CD can protect peptides from hydrolysis and subsequent loss of ability.
Prevent Heat-induced Changes
Another important problem event is the thermal degradation of natural compounds. In most cases, heating will lead to the volatilization of unstable compounds, which may have interesting biological characteristics. One possible solution is to encapsulate bioactive compounds with cyclodextrin to form a complex, which provides a barrier to prevent their loss. For example, the system has been used to encapsulate vitamin A palmitate in vitro to produce fortified food using β-CD.
How to Transport and Store BSES Powder?
For the transportation of BSES, if you buy it in commercial order quantity, you can transport it by sea. For a small quantity, we can deliver it for you by express or air. It is a very safe chemical and suitable for air transportation. It has a certificate of safe air transport. There is no need for ice packs or cold chain storage during transportation. The storage of sulfobutyl-β-cyclodextrin must be sealed in airtight inner packaging and protected from light. Because of its hygroscopicity, it is easy to absorb moisture from the air. If it is not well sealed, moisture will affect its quality. Although it is relatively stable, it is recommended to store it in a strong container to avoid heat and light. You can store it at room temperature to ensure that there is no big temperature fluctuation. Its shelf life is 2 years. Be sure to run tests before using them.
- Read the Patient Information Leaflet if available from your pharmacist before you start using it and each time you receive this medication. If you have any questions, ask your doctor or pharmacist.
- This medication is given by a health care professional. It is injected slowly into a vein over 15 to 30 minutes.
- The dosage and treatment schedule are based on your medical condition, lab tests, and response to treatment.
- You should receive this medication regularly to get the most benefit from it. To help you remember, mark your calendar to keep track of when to receive the next dose.
- It may take several months before you see a benefit from this drug.
Overall, we can conclude that the use of cyclodextrins in medicinal products is unlikely to pose a risk.
Due to the nature of cyclodextrins, it is not easy to calculate accurate thresholds that trigger labeling, including quantitative information and safety claims in package inserts. Complicating factors are that not all studies were conducted using cyclodextrins alone, and the effects and adverse effects of cyclodextrins that may affect the active substance of the medicinal product reflect the effects of the entire product.
The effects in humans are expected, as seen in studies with and without active substances. Based on the data, it can be concluded that at 20 mg/kg/day, no serious adverse effects were expected and no adverse effects were expected by all routes of administration. Above 20 mg/kg/day, cyclodextrin may show some activity and due to insufficient safety data in children under two years of age, it is recommended that the physician be informed about the amount of cyclodextrin in the product and for use in children under two years of age. suggestions. Theoretically, cyclodextrins in excess of 200 mg/kg/day may cause digestive problems when administered orally and mild nephrotoxicity when administered parenterally.
Safe treatment time is considered to be at least three weeks, but may be much longer. It is important to emphasize that due to their complex behavior, the development and safety of cyclodextrins should take into account the assessment of specific medicinal products for their safety and should therefore be clearly stated in the SmPC.
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Frequently Asked Questions of Betadex Sulfobutyl Ether Sodium
Q: What is Betadex Sulfobutyl Ether Sodium?
Q: What is the molecular weight of Sbecd?
Q: What is the HSN code for Betadex sulfobutyl ether sodium?
Q: What is the structure of sulfobutylether beta cyclodextrin?
Q: What is sulfobutylether beta cyclodextrin sodium?
Q: What does beta Cyclodextrin do?
Q: What are the limitation of cyclodextrin?
Q: What is the difference between beta and gamma-cyclodextrin?
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Q: Is beta cyclodextrin safe?
Q: What are the health benefits of cyclodextrin?
Q: Is cyclodextrin safe in food?
Q: What is the chemical structure of Betadex?
Q: Is cyclodextrin safe for skin?
Q: Do cyclodextrin supplements work?