Salicylic acid (Salicylic acid, referred to as SA, chemical name o-hydroxybenzoic acid), has bactericidal, anti-corrosion, anti-inflammatory, anti-rheumatic and other pharmacological activities, is widely used in medicine and other fields. Salicylic acid is also one of the commonly used ingredients in cosmetics, used in skin whitening, acne and other effects.
However, salicylic acid is fat-soluble acid, which is strongly irritating to the skin, so its application is limited.
According to hydration theory and permeability principle, cyclodextrin is easily soluble in water, when the stratum corneum cells are in a hydrated state, the cells will expand, so that its structural density decreases, the cuticle distribution coefficient of cyclodextrin increases, so that the diffusion rate of the skin layer increases, so that it is easier to pass through the skin stratum corneum (osmotic enhancer), and promote the probability of cosmetics through the stratum corneum.
At present, our company - Shandong Binzhou Zhiyuan Biological Co., Ltd. produces packaged salicylic acid with 10%, 40%, 50% content, to provide perfect solutions for different customer needs. Among them, 40% salicylic acid can reach a fully dissolved state at room temperature, which is well recognized by cosmetic customers. The microencapsulated salicylic acid was prepared by cyclodextrin derivatives, which had high content of salicylic acid, low irritation, double release of salicylic acid and long action time. Can be used to prepare cosmetics that contact the skin, such as lotion, cream, water, etc. It is used for sterilization, relieving itching, clearing pores, updating and loosening.
