Uses of sodium sulfobutyl-β-cyclodextrin
Sodium sulfobutyl-β-cyclodextrin is an anionic highly water-soluble cyclodextrin derivative that can form a non-covalent complex with drug molecules, thereby improving the stability, water solubility, and safety of the drug, reducing nephrotoxicity, alleviating drug hemolysis, controlling the drug release rate, and masking bad odors. It has been widely used in injectables, oral drugs, nasal drugs, and ophthalmic drugs, and has a special affinity for nitrogen-containing drugs.
Sodium sulfobutyl-β-cyclodextrin is a multi-substituted derivative of natural β-cyclodextrin (β-CD), which is obtained by substitution reaction of 1,4-butane sultone with the hydroxyl groups on the 2-, 3-, and 6-carbons of β-CD under alkaline conditions. In pharmacy, sodium sulfobutyl-β-cyclodextrin is mainly used to increase drug solubility, improve drug stability, promote drug absorption, and reduce drug stimulation to the body. It can also be used in sustained-release preparations and targeted preparations. Compared with β-CD, sulfobutyl-β-cyclodextrin sodium has stronger inclusion capacity and solubilization effect, higher safety, and overcomes the limitations of β-CD such as low water solubility and renal damage. When it is used as an excipient for some drugs, it can reduce the toxic effects of drugs and improve the in vivo safety of drugs. In short, sulfobutyl-β-cyclodextrin sodium has advantages that other cyclodextrin derivatives cannot match, and it is an excipient with great application value.
Application of sulfobutyl-β-cyclodextrin sodium in preparations
Sulfobutyl-β-cyclodextrin sodium has high safety. As an injection excipient, it can increase the solubility of drugs, improve the stability of drugs, reduce the irritation of injections to the administration site, enable drugs to quickly reach the required blood drug concentration, and prolong the duration of drug action. It can be used as a solubilizer and stabilizer. It has been used in preparations such as voriconazole, remdesivir, carfilzomib, ziprasidone mesylate, maropitant, aripiprazole, posaconazole, carbazine, and phenylalanine mustard.
