Hydroxypropylbeta Cyclodextrin is β- A hydroxyalkylated derivative of cyclodextrin. It is a relatively thorough study on the application scope of toxicological tests related to preparation methods in recent years β - One of the derivatives of CD. HP- β- CDs can not only communicate with β- CD has excellent enveloping effect on many compounds, improving the stability of the enveloped substances, and it also has high water solubility and improves the release rate and bioavailability of enveloped drugs in organisms. Therefore, HP- β- CD has some special and excellent characteristics, a wider range of applications, and has a promising future in medicine.
β- HP generated after hydroxyl groups in CD are replaced by propyl groups- β- CD, apart from its non reducible molecules, is very stable in alkaline media, can be decomposed by strong acids, has molecular enveloping effects, and is non-toxic to humans β- Compared to CD, it also has the following characteristics: β- The CDs are different. for example
1. HP - β CD has a high solubility in water at room temperature, usually exceeding 50%, so it cannot crystallize in alcohol water solutions.
2. HP - β - CD and β The selectivity of CD to the enveloped substances may vary, and the molecular ratio of certain substances may vary.
3. HP - β CD is basically not metabolized or accumulated in the human body, and oral administration of HP - β The vast majority of CDs are excreted from the body through defecation, while non intestinal administration is mostly excreted through urine.
4. HP - β CD can promote the rapid release of encapsulated substances in organisms.
5. HP - β - CD ratio β - CD or other derivatives such as methylation- β CD has low surface activity and lower hemolytic activity, making it safer to use.
Due to HP - β CD has the above characteristics, so it is increasingly receiving widespread attention in the pharmaceutical industry. The hydroxypropylbeta Cyclodextrin produced by Shandong Binzhou Zhiyuan Biology has made in-depth research on the nature, preparation process, stability, pharmacology, toxicology, teratogenicity, mutagenicity, carcinogenesis, hemolysis and irritation of hydroxypropylbeta Cyclodextrin. The prepared Inclusion compound can significantly improve the drug stability, increase the solubility and bioavailability of insoluble substances, and reduce side effects of drugs, Cover up the unpleasant odor of drugs, etc.
