Methyl Beta Cyclodextrin (MβCD)
Methyl beta cyclodextrin (MβCD) Methyl-beta-cyclodextrin is a cyclic oligosaccharide composed of glucose molecules. It is a mixture of several methylated beta-cyclodextrins.
It is commonly used as an excipient which can improve drug solubility, stability, and bioavailability in the pharmaceutical industry field . Have finished China CDE record, CDE No.: F20210000272
Quick Details
|
Name |
Methyl betacyclodextrin (MβCD) |
|
CAS No. |
128446-36-6 |
|
Molecular Formula |
C42H70‐nO35.(CH3)n |
|
Average degree of substitution |
7.0~13.3 |
|
Appearance |
White or almost white powder;Odorless,slightly sweet; Freely soluble in water and methanol, soluble in ethanol and ethylene glycol, almost insoluble in cyclohexane and ethyl acetate. |
|
Assay |
≥98％ |
|
Classification |
Pharmaceutical Grade |
|
Availability |
In stock |
|
Production capacity |
200000 kg/year |
Company Overview
Shandong Binzhou Zhiyuan Biotechnology Co., Ltd is a leading high-tech enterprise specializing in the research, development, and production of innovative cyclodextrin materials. Since its establishment in 2010, the company has built a 30,000-square-meter facility featuring 10,000 square meters of construction area, including 2,000-square-meter GMP-certified workshops and 2,000-square-meter R&D and testing laboratories equipped with advanced instruments such as HPLC, GC, CE, IC, and IR, valued at over 20 million RMB. With fixed assets exceeding 300 million RMB, the company maintains strong academic collaborations with prestigious institutions like Nankai University, Shandong University, and China Pharmaceutical University. Operating under strict GMP standards and holding ISO 9001 certification, the company's products, including Hydroxypropyl Betadex (HP-β-CD) and Betadex Sulfobutyl Ether Sodium (SBECD), have obtained CFDA registration, USFDA DMF filings, and EDQM CEP Certification (2023). Widely used in pharmaceuticals, cosmetics, functional foods, and environmental protection, these high-quality cyclodextrin products are exported globally to Europe, the Americas, Japan, Korea, and other regions, earning consistent recognition and praise from international customers through rigorous audits.
Product Introduction
Methyl betacyclodextrin (MβCD) has a larger surface tension.
Enhanced solubility: Methyl-beta-cyclodextrin has high solubility in water, which helps improve the solubility of poorly water-soluble drugs, thereby increasing their bioavailability and efficacy.
Surfactant properties: Methyl-beta-cyclodextrin acts as a surfactant, improving the solubility and stability of drugs and cosmetics, facilitating their uniform dispersion in formulations.
Chemical stability: Methyl-beta-cyclodextrin can protect drug molecules from the detrimental effects of light, oxygen, and other environmental factors, enhancing the chemical stability and durability of drugs.
Drug delivery enhancer: By forming inclusion complexes, methyl-beta-cyclodextrin enhances the solubility and permeability of drugs, promoting their absorption and delivery in the body.
Encapsulation and masking: Methyl-beta-cyclodextrin can encapsulate molecules with unpleasant tastes or odors, improving the taste and odor of drugs or cosmetics, thereby enhancing product acceptability.
Stability enhancer: Methyl-beta-cyclodextrin can enhance the stability of drugs or cosmetics, prolonging their shelf life and preventing ingredient degradation and deterioration.
Product Specification
|
Name |
Methyl betacyclodextrin (MβCD) |
|
ITEMS |
SPECIFICATION |
|
Assay |
≥98％ |
|
Specific rotation |
+154°～+165° |
|
Water solution pH |
pH5.0～7.5 |
|
Light-absorbing impurities |
Between 230 nm and 750 nm,the absorbance is not greater than 1.0; |
|
Average Degree of Substitution |
7.0~13.3 |
|
Beta Cyclodextrin |
≤0.2% |
|
The total aerobic microbial count |
≤1000cfu/g |
|
The total combined moulds and yeasts count |
≤100cfu/g |
|
Escherichia coli |
Absence |
Important partners
Application
Some Application examples of methyl-beta-cyclodextrin in the pharmaceutical and cosmetics industries:
★ Enhanced drug solubility: Methyl-beta-cyclodextrin can be used as a solubility enhancer in drug formulations to improve the solubility of poorly soluble drugs. For example, it can be used in oral medications to increase the dissolution and absorption of drugs in the gastrointestinal tract.
★ Improved drug stability: Methyl-beta-cyclodextrin can protect drug molecules from the effects of light, oxygen, and other adverse environmental factors, thereby enhancing the chemical stability of drugs. This is particularly useful for preparing sensitive drugs or formulations requiring long-term stability.
★ Taste masking: Methyl-beta-cyclodextrin can be used to mask the unpleasant taste or odor of drugs or cosmetics, improving the taste and acceptability of the products. For example, it can be utilized in the preparation of oral sprays or liquid medications to enhance the patient's experience.
★ Enhanced cosmetic stability: Methyl-beta-cyclodextrin can be used as a stabilizer in cosmetics, prolonging the shelf life of products and protecting active ingredients from light and oxygen damage. It can be applied in skincare products, makeup, and personal care items.
★ Fragrance and perfume formulation: Methyl-beta-cyclodextrin can be used in the preparation of fragrances and perfumes to stabilize and prolong the release of fragrance components, increasing their longevity and stability.
Packing & Storage
● Internal packing: packed PE bag, then put into aluminum foil bag
● Storage: Preserve well-closed containers protect from moisture.
● Label: according to customers' request.
● Outer packing: packed in drum.
● Packing:100g/bag, 1kg/bag, 2kg/bag, 10kg/bag/drum, 20kg/bag/drum
Delivery
1
Stock:
Goods in stock
2
Delivery:
Delivery goods within 1-3 workdays.
3
Loading location:
factory of Binzhou Zhiyuan(China)
4
Shipping:
FOB, CIF, CFR, DDU.....
Our advantages
High quality with competitive price.
All purity>99%.
We are manufacturer, factory price.
Fast and safe delivery.
Goods can be sent out in 24 hours after payment tracking number available.
Secure and discreet shipment verious transportation methods for your choice.
Complete production and inspection facilities
FAQ-Quality Control
Q: Do you have Raw material(includes Packaging material) specifications?
Q: Who performs the analytical tests: Inside laboratory
Q: Do you keep a reserved sample from each batch of cyclodextrin product? For how long time?
Q: Do you have Product specifications?
Q: Please detail all solvents used in the manufacture of the product?
Q: Is final inspection / testing performed by QC on each batch?
Q: Do you maintain records on the tests you perform?
Q: Will you provide a Certificate of Analysis for each lot or batch if required?
Q: Can you send a copy of your specifications and a sample of your Certificate of Analysis.
Q: Is test equipment calibrated?
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