Fenbendazole is a widely used anthelmintic drug, effective in treating parasitic infections in both humans and animals. However, its poor water solubility limits its bioavailability and therapeutic effectiveness. Cyclodextrins, particularly methyl-β-cyclodextrin (M-β-CD), have been employed to enhance the solubility and stability of poorly soluble drugs. This article explores the application of M-β-CD in the inclusion complex formation with fenbendazole to improve its solubility and bioavailability.
Results and Discussion
Solubility Enhancement
The solubility of fenbendazole significantly increased upon inclusion with M-β-CD. The aqueous solubility of the inclusion complex was markedly higher than that of pure fenbendazole, demonstrating the effectiveness of M-β-CD in improving drug solubility.
Bioavailability Improvement
Pharmacokinetic studies indicated that the inclusion complex of fenbendazole with M-β-CD exhibited enhanced bioavailability compared to the free drug. This improvement is attributed to the increased solubility and stability provided by the M-β-CD inclusion complex.
Stability
The stability of fenbendazole was also improved through complexation with M-β-CD. The inclusion complex showed better resistance to environmental factors such as light and temperature, which can degrade the free drug.
Conclusion
The application of methyl-β-cyclodextrin in the inclusion of fenbendazole proves to be a promising strategy to enhance the solubility, bioavailability, and stability of this important anthelmintic drug. This approach can potentially lead to more effective treatments for parasitic infections by improving the therapeutic performance of fenbendazole. Further research could explore the clinical implications and scalability of this method for broader pharmaceutical applications.
