Cationic Cyclodextrin

People pay attention to the positively charged cyclodextrins and other positively charged molecules.Such as dendrimers polymers, and various oligomers.

The interest arises mainly form the coexistence of a CD cavity for molecular entrapment and a positively charged corona that can additionally stabilize the inclusion via electrostatic forces. More over, positively charged CDs may act as catalysts of various organic reactions, form supramolecular capsules in solution with negatively charged CDs, encapsulate anionic guest such as nucleotides, act as inhibitors of virulence factors by blocking the pores of pore-forming proteins, and finally act as cell penetrating (CPCDs) and DNA delivery agents. Therefore cationic CDs constitute a remarkable family of drug delivery molecules with high potential and diverse applications.

Cationic Cyclodextrin belongs to chemically modified Cyclodextrin. It is an amine containing Cyclodextrin ether derivative with positive charge on the nitrogen atom, which is produced by etherification of various halogenated or epoxy based organic amine compounds with hydroxyl groups in Cyclodextrin molecules.

Cationic cyclodextrin demonstrates its excellent characteristics in terms of high dispersion, good solubility, high stability, and weak sedimentation in the following aspects:

1.Dispersion: Cationic cyclodextrin effectively disperses in solution, mixing uniformly with other substances to form a stable dispersion system, showcasing outstanding dispersion properties in various applications.

2.Solubility: Cationic cyclodextrin exhibits good solubility, quickly dissolving in water or other solvents, making it easier to handle in preparation processes and aiding in enhancing solubility and bioavailability.

3.Stability: Cationic cyclodextrin possesses high stability, maintaining its performance and structure under different conditions to ensure that the product is not easily affected or degraded during storage and use.

4.Sedimentation: Cationic cyclodextrin shows weak sedimentation tendencies, remaining evenly dispersed in solution without significant settling or precipitation, facilitating better results in various applications.

Cationic Cyclodextrin has a promising prospect in the fields of printing and dyeing, paper making, petrochemical, sewage treatment, daily chemical and other applications. It has high research and application value in Molecular recognition, mimic enzyme and chromatographic chiral separation.

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