Hydroxypropyl-γ-Cyclodextrin (HP-gamma-CD)

1.The company has built a high-standard GMP workshop.

Reliable quality, advanced technology and stable products

2.Key indicator control

Zhiyuan biological products all have independent intellectual property rights. Over the years, they have passed the approval of Pfizer, Johnson & Johnson, Gilead Sciences, Simcere Pharmaceuticals, Livzon

Audit of pharmaceutical companies. The products are sold to many countries and regions such as Europe, the United States, Japan, South Korea, India, Pakistan, South America, and the Middle East, and have received great recognition and praise!

(2-Hydroxypropyl)-γ-cyclodextrin belongs to the class of cyclodextrin derivatives, which exhibit a greater extent of solubility in water compared to their parent compounds. It is widely used in parenteral formulations and solid dosage forms to aid in the improvement of their stability, dissolution, bioavailability, etc.
 

Note: (Temperature T=25 ℃) Take 0.5g of solute and dissolve it with the minimum amount of corresponding reagent.

The outer rim of Cyclodextrin is hydrophilic while the inner cavity is hydrophobic, so it can provide a hydrophobic binding site like an enzyme, and act as a host to envelope various appropriate guests, such as organic molecules, inorganic ions and gas molecules. Cyclodextrin is an ideal host molecule similar to enzyme, and it has the characteristics of enzyme model itself.

Gamma-Cyclodextrin 2-hydroxypropyl ethers [128446-34-4] is a water-soluble alkylated cyclodextrin derivative. In the Pharmaceutical field,The main functions are as follows：

(2-Hydroxypropyl)-γ-cyclodextrin can effectively increase drug solubility, stability,Bioavailability;

It can regulate the release rate and time of the drug to achieve better therapeutic effect;

CAS No : 128446-34-4 can reduce the unpleasant odor or bitterness of drugs; Reduce the stimulation and toxic side effects of drugs;

It can make the drug sustained-release and improve the dosage form;

It is used for the dissolution of macromolecules and cell culture applications.

It has been used to study its inhibitory effect on complement products and the inflammation induced by cholesterol crystals (CC) in plasma samples.

(2-Hydroxypropyl)-γ-cyclodextrin, a cyclodextrin derivative, offers several advantages in pharmaceutical applications:

Improved drug stability: Enhances the shelf life of drug formulations by protecting drugs from degradation and oxidation.

Enhanced dissolution rate: Improves the solubility and dissolution of poorly soluble drugs, increasing their effectiveness.

Increased bioavailability: Improves the proportion of drug absorbed into the bloodstream, optimizing therapeutic response.

Taste masking and odor elimination: Masks unpleasant tastes and odors of drugs, improving patient acceptability.

Versatile formulation capabilities: Compatible with various dosage forms, allowing for flexible and tailored formulations.

Safety and regulatory approval: Well-studied and approved for use in pharmaceuticals, ensuring its safety and efficacy.

Overall, (2-Hydroxypropyl)-γ-cyclodextrin is a valuable ingredient that enhances drug stability, solubility, bioavailability, and patient acceptability in pharmaceutical formulations.

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