Acrylic Beta-Cyclodextrin (β-CD-AA)

Acrylic Beta-Cyclodextrin (β-CD-AA) is a modified cyclodextrin derivative with synergistic performance, combining the advantages of natural β-CD and acrylic functional groups:

✅ Superior Inclusion Capacity: Maintains the hydrophobic cavity structure of β-CD (cavity diameter: ~0.65 nm), enabling stable inclusion complexes with small-molecule active ingredients (molecular weight 100-400 Da), such as drugs, fragrances, and antioxidants, with inclusion efficiency up to 85-95%

✅ Enhanced Water Solubility: Compared with native β-CD (solubility: ~1.8 g/100 mL), the introduction of acrylic groups improves water solubility by more than 10 times, suitable for water-based formulations and biological systems

✅ Controllable Chemical Tunability: The degree of substitution (1.0-4.0) can be customized according to application requirements; the reactive double bonds (-C=C-) allow copolymerization with monomers such as acrylamide, N-isopropylacrylamide, and acrylic acid, enabling the design of polymers with tailored properties (e.g., responsiveness, mechanical strength)

✅ Excellent Biocompatibility: In vitro cytotoxicity test (MTT assay) shows cell viability ≥ 90% at a concentration of 5 mg/mL (L929 cells), meeting the biocompatibility requirements for biomedical and cosmetic applications

✅ Stable Performance: Resistant to hydrolysis under neutral and weakly acidic/basic conditions (pH 5.0-9.0); thermal stability up to 120℃ (decomposition temperature > 200℃), ensuring compatibility with common processing technologies (e.g., mixing, coating, polymerization)

Acrylic Beta-Cyclodextrin (β-CD-AA) is a high-performance modified cyclodextrin derivative, integrating the unique inclusion capacity of natural β-CD with polymerizable acrylic functional groups.

1. Drug Delivery & Controlled Release

Core Application: Construct pH-sensitive hydrogel drug carriers for oral, topical, or injectable formulations

Technical Principle: The acrylic double bonds polymerize to form crosslinked hydrogels; the β-CD cavity loads poorly soluble drugs (e.g., paclitaxel, curcumin), and the hydrogel swells/degrades in response to intestinal pH (pH 6.8-7.4), achieving targeted release

Practical Value: Improves the solubility of poorly soluble drugs by 5-20 times; extends drug release time to 12-24 hours (sustained release); reduces side effects by avoiding drug release in the stomach (pH 1.0-3.0); validated in preclinical studies for anti-tumor, anti-inflammatory, and antibacterial drug delivery

Typical Formulations: Oral sustained-release tablets, transdermal drug patches, injectable microgels

2. Smart Materials & Biomedical Engineering

Smart Antibacterial Coatings: Copolymerizes with antibacterial monomers (e.g., quaternary ammonium salts) to form pH/temperature-responsive coatings for medical devices (catheters, implants); the coating releases antibacterial agents on demand when exposed to bacterial biofilm (pH ~5.5-6.0), achieving long-term antibacterial effects (≥ 7 days) with antibacterial rate > 99% against E. coli and S. aureus

Tissue Engineering Scaffolds: Crosslinks with gelatin/hyaluronic acid to prepare porous scaffolds (pore size: 100-300 μm) for skin, bone, or cartilage repair; the β-CD cavity loads growth factors (e.g., VEGF, BMP-2) for controlled release, promoting cell proliferation and tissue regeneration; the scaffold has a compressive modulus of 5-20 kPa, matching the mechanical properties of soft tissues

Wound Dressings: Integrates with hydrocolloids to form moisture-retentive dressings; loads antibacterial drugs and growth factors, accelerating wound healing by 30-50% compared to conventional dressings

3. Adsorption & Separation Materials

Heavy Metal Ion Removal: Polymerizes to form porous adsorbent beads (particle size: 1-3 mm) with β-CD cavities as adsorption sites; specifically adsorbs Pb²⁺ (adsorption capacity: 80-120 mg/g), Zn²⁺ (60-90 mg/g), Cu²⁺ (50-80 mg/g), and Cd²⁺ (40-70 mg/g) from industrial wastewater

Technical Advantages: High selectivity (adsorption selectivity coefficient Pb²⁺/Ca²⁺ > 50); fast adsorption rate (equilibrium time: 30-60 minutes); good regeneration performance (can be reused ≥ 5 times with acid washing, adsorption capacity retention ≥ 85%); compliant with environmental discharge standards (treated water heavy metal content ≤ 0.05 ppm)

Application Scenarios: Electroplating wastewater treatment, mining wastewater purification, drinking water purification

4. Functional Additives (Cosmetics & Food Industry)

Cosmetics: Used as a stabilizer and solubilizer in skincare, haircare, and sunscreen products;

Stabilizes sensitive ingredients: Protects vitamins (C, E), retinol, and fragrances from oxidation and photodegradation, extending product shelf life by 1-2 years;

Improves solubility: Solubilizes oil-soluble active ingredients (e.g., coenzyme Q10, squalane) in water-based formulations, avoiding phase separation;

Enhances efficacy: Promotes the penetration of active ingredients into the skin stratum corneum, improving moisturizing, anti-aging, and whitening effects

Food Industry: Functions as a food additive (E-number pending approval) for:

Stabilizing food pigments (e.g., β-carotene, anthocyanins) and flavors, preventing degradation during processing and storage;

Reducing bitterness/off-flavors (e.g., in soy products, functional foods) by encapsulating bitter compounds;

Improving the stability of probiotics in functional foods, enhancing their survival rate in the gastrointestinal tract (survival rate ≥ 80% vs. ≤ 50% without encapsulation)

● Packing: 1kg/2kg/10kg/20kg/drum or carton

● Storage: Preserve well-closed containers protect from moisture.

● Inner packaging: sterile PE bag, aluminum foil bag;

● Outer packaging: full carton;

Hot Tags: acrylic beta-cyclodextrin (β-cd-aa), China acrylic beta-cyclodextrin (β-cd-aa) manufacturers, suppliers, leisure product, souvenir product, gift product, attractive product, newly launched product, special interest product